Dienekes’ Anthropology Blog

These results provide some support for a link between genetic variety and a measure of general, everyday health in humans. We found a small, but significant, effect of nonMHC genetic variety, measured as standardized mean-d2, on health. People with better nonMHC-d2 reported fewer symptoms more than a four-month period than less diverse individuals significantly, with nonMHC-d2 accounting for 3% of the variance in health.

Does Genetic Diversity Predict Health in Humans? Hanne C. Lie et al. Genetic diversity, especially at genes very important to immune functioning within the Major Histocompatibility Complex (MHC), has been associated with fitness-related attributes, including disease level of resistance, in many species. Recently, genetic variety has been associated with mate preferences in humans. Here we asked whether these preferences are adaptive in conditions of obtaining healthier mates. We looked into whether genetic variety (heterozygosity and standardized mean d2) at MHC and nonMHC microsatellite loci, expected health in 153 individuals. People with greater allelic diversity (d2) at nonMHC loci and at one MHC locus, associated with HLA-DRB1, reported fewer symptoms over the four-month period than people with lower d2.

In contrast, there were no organizations between MHC or nonMHC health and heterozygosity. NonMHC-d2 has been found to anticipate male choices for female faces previously. Thus, the current findings claim that nonMHC diversity may play a role in both natural and sexual selection functioning on human populations. 2 responses: Email ThisBlogThis!

Previous research has shown that encounters of MHC heterozygous males are judged more appealing. The new study confirms the results of the sooner one, by finding a preference of females to MHC heterozygous men, with MHC heterozygosity being predictive of facial averageness in both sexes. Hanne C. Lie et al. From an evolutionary perspective, human facial elegance is proposed signal mate quality. Utilizing a novel approach to the analysis of the genetic basis of individual preferences for cosmetic features, we investigated whether attractiveness indicators mate quality in conditions of genetic diversity.

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Genetic diversity in general has been linked to fitness and reproductive success, and hereditary variety within the major histocompatibility complex (MHC) has been associated with immunocompetence and mate preferences. We asked whether any preference for genetic variety is specific to MHC variety or reflects a far more general preference for overall genetic diversity.

We photographed and genotyped 160 individuals using microsatellite markers situated within and beyond your MHC, and determined two steps of genetic variety: mean heterozygosity and standardized mean d2. Our results suggest a particular role for the MHC in female preferences for male encounters. MHC heterozygosity favorably forecasted man appeal, and specifically facial averageness, with averageness mediating the MHC-attractiveness relationship.